The Neuro-Developmental Lab, a Joint lab between the Institute for Cognitive and Brain Sciences and Faculty of Biological Sciences, Shahid Beheshti University, was established in 2015 (1394). This lab is located at the Faculty of Biological Sciences building and is equipped with
- 3-chamber boxes;
- Open field boxes;
- CCD cameras;
- and a water maze.
Researchers can use the lab facilities since March 2016. In order to book a session, please contact Dr. Mohammad Reza Bigdeli through email@example.com.
Available research lines in the neuro-developmental lab are:
1. MicroRNA arrays lab (agomir/ antagomir): The role of microRNA changes in ischemic stroke and autism spectrum disorder.
Definition: Epigenetic is defined as mitotically and meiotically heritable fluctuations in gene expression that do not relate to the changes in DNA sequences.
Aims: The survey of microRNA on epigenetics machinery.
Project Manager: Mrs Aniseh Talebi (PhD student)
2. Neuroinflammation: Assessment of blood biomarkers and pro-inflammatory factors in ischemic stroke and autism spectrum disorder.
Definition: Neuroinflammation is a common phenomenon in the pathophysiology of many brain diseases including ischemic stroke and autism spectrum disorder.
Aims: Assessment of blood biomarkers in autism spectrum disorder and ischemic stroke.
Project Manager: Mrs Elham Javaheri (PhD student)
3. Cellular receptor analysis and cytopathology: Prognosis and early diagnosis of structural and functional talent of brain tissue to stroke and autism spectrum disorder by single nucleotide polymorphism of cellular receptor.
Definition: Single-nucleotide polymorphisms can fall within coding and non-coding sequences of genes. Single nucleotide polymorphisms predict the susceptibility and symptom severity of autism spectrum disorder and ischemic stroke.
Aims: Seeking the symptom severity and susceptibility to stroke and autism spectrum disorder. Single-nucleotide polymorphisms may make a person more susceptible to autism spectrum disorder and ischemic stroke.
Project Manager: Mrs Samaneh Sheikhi (PhD student)
4. Histo-techniques and cytopathology: Cellular and histological approach in the assessment of various biomarker in post-mortal human and animal tissues.
Definition: Histopathology refers to the examination of biopsy or post-mortal human and animal tissue, after the mentioned tissue has been processed and histological serial sections have been placed onto glass slides.
Aims: The examination of the histological changes in post-mortal human and animal tissue in different types of brain disorders in specific region.
Project Manager: Mrs Milanizadeh (PhD student)
5. Optogenetics: Novel tools for controlling mammalian cell functions with light and new method for regulation of membrane excitability and cellular measurements.
Definition: The optogenetic manipulations involve altering the membrane potential of electrically excitable cells by illuminating them with controlled bursts of light.
Aims: Optogenetic actuators (like channelrhodopsin and halorhodopsin) for controlling mammalian neuron, and optogenetic sensors (GCaMP: calcium indicator for neural activity imaging) for recording of neuronal activities.
Project Manager: Dr Sepideh Khaksar (PhD)